PHARMACOLOGICAL CORRECTION OF THE PURULENT PROCESS OF WOUND BY PHYTOMINERALSORBENTUM IN RATS

Sorbtions and biological active compounds are perspective drugs for treatment of the purulent wounds. Results of the wound healing with phytomineralsorbent are shown in this article. Relative characteristic of phytomyneralsorbent and Dexpanthenol (Russia, Pharmstandard) was done on purulent injury of rat. Simulation of a purulent wound was applied to the area between the shoulder blades of Wistar rats. Infection was carried out with a hospital strain of Escherichia coli. Wound dressings were performed by the investigated agents in doses of 1 mg on injury of the animal during all phases of injury healing (21 days). Evaluation of the wound healing effect was performed on histological sections with early hematoxylin-eosin stained and dynamic of increasing wound surface. The wound defect of rats, which was treated by phytomineralsorbent, was significantly less than control in 2 times. The depth of necrosis in the inflammatory phase of the wound process was up to 0,85 microns deep, which is 1,7 times less than in control group. Using Dexpanthenol was characterized by a suppuration reaction and the presence of microbes. Thus, the use of phytomineral containing agents promotes a better healing of a purulent wound in the acute phase of the wound process.