Determination of Minimum Inhibitory Concentrations of 4,4’-diacetyldiphenylselenide in Antibacterial Activity

Aim: The present study was focused on evaluation of antibacterial activity of 4,4’-diacetyldiphenylselenide against some bacterial species.

Introduction: Many compounds containing selenium element, notably 4,4’-diacetyldiphenylselenide, have started getting a great pharmacological interest as bioactive molecules insofar as the -In vitro - antimicrobial tests were carried out on different bacterial strains.

Methodology: The 4,4’-diacetyldiphenylselenide was synthesized in our laboratory and reported for the first time in 2010. The studied bacterial strains were collected from different places, some ones are standard strains and the others were clinically isolated and identified by biochemical tests.

The antibacterial property was evaluated via determination of Minimum Inhibitory Concentrations (MIC) using dilution method in the same conditions.

Results and Discussion: The most effective MICs are achieved at 16 µg/ mL for Providencia rettgeri, 32 µg/ mL for Salmonella typhimurium, 88 ±11.31 µg/ mL for Serratia liquefaciens, 128 µg/ mL for Shigella dysenteriae, 144 µg/ mL for Morganella morganii, 200 µg/ mL , 200 ± 11.31 µg/ mL for Proteus mirabilis and Acinetobacter baumannii respectively.

Conclusion: This study showed that 4,4’-diacetyldiphenylselenide is a bacteriostatic agent at determined Minimum Inhibitory Concentrations (MIC) against several pathogenic bacteria.