Pharmacological Study of Dopamine Receptors Agonist and Antagonist on Mouse Model of Myocardial Injury

Objective: The present study was designed to evaluate the potential protective effect of using mix of bromocriptine 7 mg/kg & metoclopromide 3 mg/kg on the inflammatory biomarkers AST, ALT and LDH1 against isoprotrenol-induced myocardial injury (MI) in mice model.

Methodology: Study the effect of dopamine, bromocriptine and metoclopramide on the blood pressure, myocardial inflammatory biomarkers and histological structure of the myocardial tissue. 35 adult male mice were divided into seven groups (5 mice each): group I, control group; group II, isoprotrenol treated group. Group III, Mice with MI were treated with dopamine (0.5/kg/day. IP) for 30 days. Group IV, Mice with MI were treated with bromocriptine (10 mg/kg/day, IP) for 30 days. Group V, Mice with MI were treated with metoclopromide (10 mg/kg. IP) for 30 days. Group VI, Mice with MI were treated with bromocriptine (3 mg/kg) & metoclopromide (7 mg/kg) for 30 days. Group VII, Mice with MI were treated with bromocriptine (7 mg/kg) & metoclopromide (3 mg/kg) for 30 days.

Results: Isoprotrenol induced MI was confirmed by disturbance in serum and heart tissue markers enzymes such lactate dehydrodenase, aspartate transaminase, alanin tranaminase and histopathological changes in the heart of Isoprotrenol administered mice. Mice with MI were treated with bromocriptine (7 mg/kg) & metoclopromide (3 mg/kg) for 30 days was found to ameliorate the effect of isoprotrenol induced histopathological changes, retained myocardial marker enzymes activities at near normal level.

Conclusion: The above results indicate the cardioprotective effect of mix of bromocriptine 7 mg/kg & metoclopromide 3 mg/kg aganist isoprotrenol-induced myocardial injury in mice.